Hepatocyte spheroids as a competent in vitro system for drug biotransformation studies: nevirapine as a bioactivation case study
ARCHIVES OF TOXICOLOGY, 91, 1199-1211
3 2017
Pedro F. Pinheiro , Sofia A. Pereira , Shrika G. Harjivan , Inês Sofia Lança Martins , Aline T. Marinho , Madalena Cipriano , Cristina C. Jacob , Nuno G. Oliveira , Matilde F. Castro , M. Matilde Marques , Alexandra Maria Moita Antunes , Joana P. Miranda
New insights into the molecular mechanisms of chemical carcinogenesis: In vivo adduction of histone H2B by a reactive metabolite of the chemical carcinogen furan
TOXICOLOGY LETTERS, 264, 106-113
12 2016
João Pedro da Costa Nunes , Inês Sofia Lança Martins , Catarina Sofia Romão Charneira , Igor P. Pogribny , Aline de Conti , Frederick A. Beland , M. Matilde Marques , Cristina C. Jacob , Alexandra Maria Moita Antunes
Modification of histone H2b in a rat model by a reactive metabolite of the chemical carcinogen and food contaminant furan
TOXICOLOGY LETTERS, 258, S92
9 2016
A. M. Antunes , J. Nunes , Inês Sofia Lança Martins , C. Charneira , I. Pogribny , A. De Conti , F. A. Beland , M. Marques , C. C. Jacob
Selenium-Containing Chrysin and Quercetin Derivatives: Attractive Scaffolds for Cancer Therapy
JOURNAL OF MEDICINAL CHEMISTRY, 58, 4250-4265
5 2015
Inês Sofia Lança Martins , Catarina Sofia Romão Charneira , Valentina Gandin , João Ferreira da Silva , Gonçalo C. Justino , J. P. Telo , Abel J. S. C. Vieira , Cristina Marzano , Alexandra Maria Moita Antunes
Protein adducts from carbamazepine-10,11-epoxide, the major metabolite of the antiepileptic drug carbamazepine: possible biomarkers of toxicity
TOXICOLOGY LETTERS, 238, S359
10 2015
Inês Sofia Lança Martins , M. Matilde Marques , Alexandra Maria Moita Antunes
Quinoid derivatives of the nevirapine metabolites 2-hydroxy- and 3-hydroxy-nevirapine: activation pathway to amino acid adducts
TOXICOLOGY RESEARCH, 4, 1565-1577
2015
Shrika G. Harjivan , Pedro F. Pinheiro , Inês Sofia Lança Martins , Ana L. Godinho , Riccardo Wanke , P P Santos , Sofia A. Pereira , Frederick A. Beland , M. Matilde Marques , Alexandra Maria Moita Antunes
Enzymatic bioactivation of the phenolic nevirapine metabolites 2-hydroxy- and 3-hydroxy-nevirapine to quinoid intermediates: Covalent adduct formation with nitrogen-based amino acids
TOXICOLOGY LETTERS, 238, S359-S360
10 2015
S. G. Harjivan , Pedro F. Pinheiro , Inês Sofia Lança Martins , D. A. Novais , R. Wanke , P P Santos , S. A. Pereira , F. A. Beland , M. Matilde Marques , Alexandra Maria Moita Antunes
Synthesis and Biological Activity of 6-Selenocaffeine: Potential Modulator of Chemotherapeutic Drugs in Breast Cancer Cells
MOLECULES, 18, 5251-5264
5 2013
Inês Sofia Lança Martins , Joana P. Miranda , Nuno G. Oliveira , Ana S. Fernandes , Sandrina Goncalves , Alexandra Maria Moita Antunes
Computational assessment of the potential role of chalcogenated flavonoids as antioxidants, enzyme inhibitors and cell signalling modulators via computational analysis
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 242,
8 2011
Alexandra Maria Moita Antunes , Gonçalo C. Justino , Inês Sofia Lança Martins , Catarina Sofia Romão Charneira , M. Matilde Marques
Amino Acid Adduct Formation by the Nevirapine Metabolite, 12-Hydroxynevirapine-A Possible Factor in Nevirapine Toxicity
CHEMICAL RESEARCH IN TOXICOLOGY, 23, 888-899
5 2010
Alexandra Maria Moita Antunes , Ana L. A. Godinho , Inês Sofia Lança Martins , Gonçalo C. Justino , Frederick A. Beland , M. Matilde Marques
Microwave-based methodology for the preparation of organoselenium compounds
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 240,
8 2010
M. Matilde Marques , Inês Sofia Lança Martins , Catarina Sofia Romão Charneira , Abel J. S. C. Vieira , Alexandra Maria Moita Antunes
Protein Adducts As Prospective Biomarkers of Nevirapine Toxicity
CHEMICAL RESEARCH IN TOXICOLOGY, 23, 1714-1725
11 2010
Alexandra Maria Moita Antunes , Ana L. A. Godinho , Inês Sofia Lança Martins , M. Conceição Oliveira , Ricardo A. Gomes , Ana V. Coelho , Frederick A. Beland , M. Matilde Marques
Protein adduct formation by the nevirapine metabolite, 12-hydroxynevirapine-A possible factor in nevirapine toxicity
TOXICOLOGY LETTERS, 189, S103
9 2009
Alexandra Maria Moita Antunes , Ana Godinho , M. Matilde Marques , Inês Sofia Lança Martins , Frederick A. Beland
Synthesis and Characterization of Amino Acid Adducts from the HIV Reverse Transcriptase Inhibitor Nevirapine
CHEMICAL RESEARCH IN TOXICOLOGY, 21, 2453
12 2008
M. Matilde Marques , Inês Sofia Lança Martins , Alexandra Maria Moita Antunes , Pedro P. Santos , Goncalo Gamboa da Costa , Frederick A. Beland